Regulatory T Cells and Myeloid-Derived Suppressor Cells in Patients with Peptic Ulcer and Gastric Cancer

Authors

  • Abolghasem Ajami Department of Immunology, School of Medicine | Molecular and Cell Biology Research Center
  • Alireza Rafiei Department of Immunology, School of Medicine | Molecular and Cell Biology Research Center
  • Hadi Hussein-Nattaj Department of Immunology, School of Medicine
  • Hamideh Mesali Department of Immunology, School of Medicine
  • Hossein Asgarian-Omran Department of Immunology, School of Medicine
  • Mohsen Tehrani Department of Immunology, School of Medicine | Molecular and Cell Biology Research Center
  • Tarang Taghvaei Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran
  • Vahid Hosseini Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran
  • Zeinab Rajabian Department of Immunology, School of Medicine
Abstract:

Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease (PUD, n=25), and gastric cancer (GC, n=27) according to their endoscopic and histopathological examinations. Helicobacter pylori infection was diagnosed by rapid urease test and histopathology. The number of peripheral blood CD4+CD25+FoxP3+Tregs and CD14+HLA-DR- MDSCs were determined in all patients, by flow cytometry. The number of FoxP3+ regulatory T cells was also determined by immunohistochemistry (IHC). Results: The percentage of peripheral blood Treg cells in both PUD )0.81 ± 0.39, p

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Journal title

volume 13  issue 3

pages  167- 177

publication date 2016-09-01

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